A Dual-Factor Releasing Hydrogel for Rotator Cuff Injury Repair

نویسندگان

چکیده

Rotator cuff injury causes pain in the shoulder and is a challenge to be repaired even after surgical reconstruction. Here, we developed dual-factor releasing hydrogel based on sulfhydrylated chitosan deliver KGN FGF-2 injured area enable fast healing of tendon–bone interface, which essential for repair rotator injury. We found that two factors could easily loaded into hydrogel, turn continuously release physiological conditions. The was porous structure through scanning electron microscope (SEM). micropores loading these molecules. This study showed play synergistic effect by recruiting promoting stem cell proliferation chondrogenesis, thus accelerating interface. An vivo rabbit model demonstrated possesses superior capacity than single-factor untreated groups. In conclusion, promising biomaterial regeneration interface repair.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Retraction pattern of delaminated rotator cuff tears: dual-layer rotator cuff repair

BACKGROUND There has been no report to date regarding retraction patterns of delaminated rotator cuff tears. The purpose of this study was to evaluate the incidence and tearing patterns of delamination and repair integrity after the dual-layer repair of delaminated cuff tears. METHODS/DESIGN A consecutive series of 64 patients with posterosuperior rotator cuff tears underwent arthroscopic rot...

متن کامل

Arthroscopic rotator cuff repair.

Arthroscopic rotator cuff repair is being performed by an increasing number of orthopaedic surgeons. The principles, techniques, and instrumentation have evolved to the extent that all patterns and sizes of rotator cuff tear, including massive tears, can now be repaired arthroscopically. Achieving a biomechanically stable construct is critical to biologic healing. The ideal repair construct mus...

متن کامل

Rotator Cuff Repair Rehabilitation

BACKGROUND There is no consensus for the optimal postoperative rehabilitation protocol after rotator cuff repairs. OBJECTIVE To determine if there is sufficient level I or II evidence available in the literature for establishment of a uniform, optimal rotator cuff rehabilitation protocol. DATA SOURCES A systematic review of level I and II English-language, prospective, randomized controlled...

متن کامل

Arthroscopic repair of complete tear of rotator cuff

 Abstract  Background: Rotator cuff tear is one of the most common causes of shoulder  complaints in the elderly. Based on the severity and patient's condition, a variety of  methods applies to manage the tear and surgery is an important method, which could  be done by open or arthroscopic technique. The current study aimed to investigate  and report short-term results of arthroscopic repair of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Materials

سال: 2021

ISSN: ['2296-8016']

DOI: https://doi.org/10.3389/fmats.2021.754973